PrimPol breaks replication barriers

Nat Struct Mol Biol. 2013 Dec;20(12):1348-50. doi: 10.1038/nsmb.2727.

Abstract

Faithful bypass of replication forks encountering obstructive DNA lesions is essential to prevent fork collapse and cell death. PrimPol is a new human primase and translesion polymerase that is able to bypass fork-blocking UV-induced lesions and to restart replication by origin-independent repriming.

Publication types

  • News
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA Primase / physiology*
  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / physiology*
  • Humans
  • Multifunctional Enzymes / physiology*

Substances

  • Multifunctional Enzymes
  • DNA Primase
  • PrimPol protein, human
  • DNA-Directed DNA Polymerase