Nalidixic acid and trimethoprim/sulphamethoxazole as alternatives for short-term treatment of urinary infections

Ann Trop Paediatr. 1986 Sep;6(3):205-7. doi: 10.1080/02724936.1986.11748440.


The efficacy of 3-day therapy with nalidixic acid in 16 children, and trimethoprim/sulphamethoxazole in 19 children, was studied prospectively in children with an acute infection of the lower urinary tract and compared with that of a conventional 10-day course with the same drugs. The immediate cure rate was 97% in the 3-day group and 90% in the 10-day group. During 3 months of follow-up there were altogether six re-infections in children given short-term treatment and six in the conventionally treated group. The results give further support for the suggestion that 3-day therapy is equivalent to 10-day treatment in uncomplicated urinary infections in children and that both nalidixic acid and trimethoprim/sulphamethoxazole are good alternatives in such an approach.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Anti-Infective Agents, Urinary / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Combinations / therapeutic use
  • Female
  • Humans
  • Infant
  • Male
  • Nalidixic Acid / therapeutic use*
  • Sulfamethoxazole / therapeutic use*
  • Time Factors
  • Trimethoprim / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Urinary Tract Infections / drug therapy*


  • Anti-Infective Agents, Urinary
  • Drug Combinations
  • Nalidixic Acid
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole