A Novel Quinazolinone Derivative as Fluorescence Quenching Off-On Sensor for High Selectivity of Fe(3+)

Ailin Yuan; Chunling Zheng; Zhengyu Zhang; Lu Yang; Chao Liu; Haibo Wang

doi:10.1007/s10895-013-1325-4

A Novel Quinazolinone Derivative as Fluorescence Quenching Off-On Sensor for High Selectivity of Fe(3+)

J Fluoresc. 2014 Mar;24(2):557-61. doi: 10.1007/s10895-013-1325-4. Epub 2013 Dec 5.

Authors

Ailin Yuan¹, Chunling Zheng¹, Zhengyu Zhang¹, Lu Yang¹, Chao Liu¹, Haibo Wang²

Affiliations

¹ Institute of Food and Light-chemical Engineering, Nanjing, Jiangsu, China.
² Institute of Food and Light-chemical Engineering, Nanjing, Jiangsu, China. wanghaibo@njut.edu.cn.

PMID: 24306092
DOI: 10.1007/s10895-013-1325-4

Abstract

A novel quinazolinone compound containing quinazoline-fused moiety has been synthesized as fluorescence Off-On sensor QQ. The probe exhibited highly selective and sensitive recognition toward trivalent ferric ion (Fe(3+)) over other metal ions in HEPES buffer solution (10 mM, pH = 7.0, DMF-H2O, 9:1, v/v). The significant quenching in the fluorescence spectral could be served as a selective fluorescence Off-On sensor. The titration study indicated the formation of 1:1 complex between QQ and Fe(3+).

Keywords: Fe3+; Fluorescent probe; Off-On; Quinazolinone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferric Compounds / chemistry*
Quinazolinones / chemistry*

Substances

Ferric Compounds
Quinazolinones