Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study

Obesity (Silver Spring). 2014 Jan;22(1):5-13. doi: 10.1002/oby.20662.

Abstract

Objective: To evaluate 8-year weight losses achieved with intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study.

Design and methods: Look AHEAD assessed the effects of intentional weight loss on cardiovascular morbidity and mortality in 5,145 overweight/obese adults with type 2 diabetes, randomly assigned to ILI or usual care (i.e., diabetes support and education [DSE]). The ILI provided comprehensive behavioral weight loss counseling over 8 years; DSE participants received periodic group education only.

Results: All participants had the opportunity to complete 8 years of intervention before Look AHEAD was halted in September 2012; ≥88% of both groups completed the 8-year outcomes assessment. ILI and DSE participants lost (mean ± SE) 4.7% ± 0.2% and 2.1 ± 0.2% of initial weight, respectively (P < 0.001) at year 8; 50.3% and 35.7%, respectively, lost ≥5% (P < 0.001), and 26.9% and 17.2%, respectively, lost ≥10% (P < 0.001). Across the 8 years ILI participants, compared with DSE, reported greater practice of several key weight-control behaviors. These behaviors also distinguished ILI participants who lost ≥10% and kept it off from those who lost but regained.

Conclusions: Look AHEAD's ILI produced clinically meaningful weight loss (≥5%) at year 8 in 50% of patients with type 2 diabetes and can be used to manage other obesity-related co-morbid conditions.

Trial registration: ClinicalTrials.gov NCT00017953.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / therapy
  • Energy Intake
  • Female
  • Follow-Up Studies
  • Health Behavior
  • Health Education
  • Humans
  • Life Style*
  • Logistic Models
  • Male
  • Middle Aged
  • Motor Activity
  • Obesity / complications
  • Obesity / therapy
  • Overweight / complications
  • Overweight / therapy
  • Treatment Outcome
  • Weight Loss*
  • Weight Reduction Programs*

Associated data

  • ClinicalTrials.gov/NCT00017953

Grant support