Abstract
Four-drug regimens, such as FIr-B/FOx schedule, can improve efficacy of first-line treatment of metastatic colorectal cancer (MCRC) patients. The present study specifically evaluates feasibility of FIr-B/FOx first-line intensive regimen in fit young-elderly MCRC patients, representing approximately 40% of overall MCRC patients. Activity, efficacy, and safety were equivalent to overall MCRC patients, not significantly different according to KRAS genotype. Clinical outcome was significantly prolonged in liver-limited compared to other/multiple metastatic disease. Safety evaluation of the individual young-elderly patient showed that limiting toxicity syndromes (LTS) in multiple sites were significantly increased, compared to LTS in single site, with respect to non-elderly patients.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antibodies, Monoclonal, Humanized / adverse effects*
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Antibodies, Monoclonal, Humanized / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bevacizumab
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Camptothecin / adverse effects
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Camptothecin / analogs & derivatives*
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Camptothecin / therapeutic use
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Carboplatin / adverse effects
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Carboplatin / therapeutic use
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Clinical Trials, Phase II as Topic
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / pathology*
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DNA Mutational Analysis
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Demography
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Dose-Response Relationship, Drug
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Female
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Fluorouracil / adverse effects
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Fluorouracil / therapeutic use
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Genotype
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Humans
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Kaplan-Meier Estimate
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Leucovorin / adverse effects
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Leucovorin / therapeutic use
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Male
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Methotrexate / adverse effects
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Methotrexate / therapeutic use
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Neoplasm Metastasis
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Organoplatinum Compounds / adverse effects
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Organoplatinum Compounds / therapeutic use
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins p21(ras)
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Treatment Outcome
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ras Proteins / genetics
Substances
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Antibodies, Monoclonal, Humanized
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KRAS protein, human
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Organoplatinum Compounds
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Proto-Oncogene Proteins
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Bevacizumab
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Carboplatin
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Proto-Oncogene Proteins p21(ras)
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ras Proteins
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Leucovorin
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Fluorouracil
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Camptothecin
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Methotrexate
Supplementary concepts
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FOLFOXIRI protocol
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Folfox protocol
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Regimen B