Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols and amines

Sandro Cacchi; Giancarlo Fabrizi; Antonella Goggiamani; Carmela Molinaro; Rosanna Verdiglione

doi:10.1021/jo401456x

Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols and amines

J Org Chem. 2014 Jan 3;79(1):401-7. doi: 10.1021/jo401456x. Epub 2013 Dec 18.

Authors

Sandro Cacchi¹, Giancarlo Fabrizi, Antonella Goggiamani, Carmela Molinaro, Rosanna Verdiglione

Affiliation

¹ Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma , P.le A. Moro 5, 00185 Rome, Italy.

PMID: 24308283
DOI: 10.1021/jo401456x

Abstract

A novel palladium-catalyzed approach to 2-(aminomethyl)indoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols and amines has been developed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Catalysis
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure
Palladium / chemistry*
Propanols / chemistry*
Stereoisomerism

Substances

Alkynes
Indoles
Propanols
Palladium
propargyl alcohol