State of the art syphilis diagnostics: rapid point-of-care tests

Expert Rev Anti Infect Ther. 2014 Jan;12(1):63-73. doi: 10.1586/14787210.2014.860356. Epub 2013 Nov 29.


Syphilis remains an important and entirely preventable cause of stillbirth and neonatal mortality. More than 1 million women with active syphilis become pregnant each year. Without treatment, 25% of them will deliver a stillborn baby, 33% will deliver a live low-birth weight baby with an increased chance of dying in the first month of life. Adverse pregnancy outcomes due to syphilis can be prevented by screening pregnant women, and treating those who test positive with a single dose of penicillin before 28 weeks gestation. Until recently access to screening in low- and middle-income countries has been limited, since screening tests have been laboratory based, requiring equipment, electricity and trained laboratory staff. Now a number of rapid, cheap, simple and accurate screening tests are available and can give a result in 15-20 min, enabling those who require treatment to be treated at their first visit.

Publication types

  • Review

MeSH terms

  • Adult
  • Female
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Point-of-Care Systems
  • Pregnancy
  • Prenatal Diagnosis
  • Syphilis / diagnosis*