Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery

Clin Invest Med. 2013 Dec 1;36(6):E297-305. doi: 10.25011/cim.v36i6.20627.


Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer.

Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m²) and overweight or obese (BMI ≥ 23.0 kg/m²). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed.

Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases.

Conclusion: A high BMI (≥ 23.0 kg/m²) is independently associated with poor prognosis in hormone receptor-positive breast cancer.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Body Mass Index*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / physiopathology*
  • Breast Neoplasms / surgery
  • Female
  • Humans
  • Middle Aged
  • Obesity / pathology*
  • Obesity / physiopathology*
  • Obesity / surgery
  • Retrospective Studies