STING-dependent cytosolic DNA sensing pathways

Trends Immunol. 2014 Feb;35(2):88-93. doi: 10.1016/j.it.2013.10.010. Epub 2013 Dec 2.

Abstract

STING (STimulator of INterferon Genes) has recently been identified as being essential for controlling host defense countermeasures triggered by microbial cytosolic DNA and subsequently cyclic dinucleotides (CDNs). However, chronic STING activation may also be responsible for initiating certain inflammatory diseases manifested by self DNA. Recent studies have also revealed a key role for cyclic GMP-AMP synthase (cGAS) in STING activation. Although a full understanding of the mechanisms of STING activation requires further studies, new insights into STING function afford the opportunity of designing novel compounds aimed at facilitating vaccine development or new therapies for the treatment of inflammatory disease.

Keywords: STING; cytosolic DNA; inflammation; interferon.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / etiology
  • Autophagy / immunology
  • Cytosol / immunology
  • Cytosol / microbiology
  • DNA / immunology*
  • Host-Pathogen Interactions / immunology
  • Humans
  • Immunity, Innate
  • Membrane Proteins / immunology*
  • Mice
  • Models, Immunological
  • Signal Transduction / immunology
  • Toll-Like Receptors / immunology

Substances

  • MPYS protein, mouse
  • Membrane Proteins
  • STING protein, human
  • Toll-Like Receptors
  • DNA