Serum levels of cytokines in systemic lupus erythematosus : Association study in a Chinese population

Z Rheumatol. 2014 Apr;73(3):277-80. doi: 10.1007/s00393-013-1274-y.


Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by abnormal production of autoantibodies and proinflammatory cytokines. The clear pathogenesis of SLE has not been fully elucidated. Cytokine-mediated immunity has been showed to be involved in the pathogenesis of SLE.

Objectives: The aim of this study was to investigate serum levels of cytokines (IL-19, IL-24, IL-26, IL-31, IL-32, IL-36) in SLE patients, in comparison with normal controls in a Chinese population.

Materials and methods: A total of 65 patients with SLE and 65 healthy volunteers were recruited for the current study. All serum levels of cytokines were measured by enzyme-linked immunosorbent assay (ELISA) kits.

Results: Serum levels of IL-19, IL-24, IL-26, IL-31, IL-32 and IL-36 in SLE patients were not significantly different from the normal controls (all p > 0.05).

Conclusion: Serum levels of IL-19, IL-24, IL-26, IL-31, IL-32 and IL-36 in SLE patients were not markedly different from the normal controls. However, functional research should be discussed in future studies to elucidate the roles of these cytokines in SLE.

Keywords: Autoantibodies; Genetic polymorphism; Interleukins; Lupus nephritis; Synovial membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers
  • China / epidemiology
  • Cytokines / blood*
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / epidemiology*
  • Male
  • Prevalence
  • Reproducibility of Results
  • Risk Factors
  • Sensitivity and Specificity


  • Biomarkers
  • Cytokines
  • Inflammation Mediators