Proton therapy verification with PET imaging

Theranostics. 2013 Sep 19;3(10):731-40. doi: 10.7150/thno.5162.


Proton therapy is very sensitive to uncertainties introduced during treatment planning and dose delivery. PET imaging of proton induced positron emitter distributions is the only practical approach for in vivo, in situ verification of proton therapy. This article reviews the current status of proton therapy verification with PET imaging. The different data detecting systems (in-beam, in-room and off-line PET), calculation methods for the prediction of proton induced PET activity distributions, and approaches for data evaluation are discussed.

Keywords: PET imaging.; proton range verification; proton therapy.

Publication types

  • Review

MeSH terms

  • Humans
  • Positron-Emission Tomography / methods*
  • Proton Therapy / methods*
  • Treatment Outcome