Abstract
A base substitution in the 5'-flanking region of a human fetal globin gene is associated with abnormal fetal hemoglobin production. It also reduces by 5- to 10-fold in vitro transcription of the gene by RNA polymerase III. We discuss potential links between polymerase III transcription and abnormal hemoglobin production.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amanitins / pharmacology
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Base Sequence
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DNA-Directed RNA Polymerases / metabolism*
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Fetal Hemoglobin / genetics*
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Genes* / drug effects
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Globins / genetics*
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Humans
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Mutation*
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RNA Polymerase III / metabolism*
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Transcription, Genetic*
Substances
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Amanitins
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Globins
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Fetal Hemoglobin
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DNA-Directed RNA Polymerases
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RNA Polymerase III