T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

Nature. 1986 Nov;324(6094):258-60. doi: 10.1038/324258a0.


Chronic relapsing paralysis and demyelination within the central nervous system (CNS), features associated with the human disease multiple sclerosis (MS), develop in mice after injection of murine T-cell clones specific for the autoantigen myelin basic protein (MBP). We examined the fine specificity of three independently derived encephalitogenic T-cell clones using synthetic polypeptides derived from portions of the N-terminal sequence of MBP. These clones appear functionally identical; they all respond to an epitope in the N-terminal nine amino acid residues in association with the same class II (I-A) molecules of the major histocompatibility complex (MHC). Both the N-terminal acetyl moiety and the first residue (Ala) are necessary for recognition. Only N-terminal MBP peptides recognized by these clones were found to cause encephalomyelitis (EAE) in vivo. These results show that the N-terminal MBP-specific T lymphocytes that mediate autoimmune encephalomyelitis are a small population with a limited repertoire; they all recognise the same combination of MHC and target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoantigens / immunology*
  • Clone Cells
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Epitopes / analysis*
  • Mice
  • Mice, Inbred Strains
  • Myelin Basic Protein / immunology*
  • T-Lymphocytes / immunology*


  • Autoantigens
  • Epitopes
  • Myelin Basic Protein