Impulsive and compulsive behaviors in Parkinson's disease

Annu Rev Clin Psychol. 2014:10:553-80. doi: 10.1146/annurev-clinpsy-032813-153705. Epub 2013 Dec 2.


Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.

Publication types

  • Review

MeSH terms

  • Compulsive Behavior / psychology*
  • Compulsive Behavior / therapy
  • Humans
  • Impulsive Behavior / psychology*
  • Impulsive Behavior / therapy
  • Parkinson Disease / psychology*
  • Parkinson Disease / therapy
  • Risk Factors