Nanoparticles strengthen intracellular tension and retard cellular migration

Nano Lett. 2014 Jan 8;14(1):83-8. doi: 10.1021/nl4032549. Epub 2013 Dec 18.

Abstract

Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion / drug effects
  • Cell Adhesion / physiology*
  • Cell Line
  • Cell Movement / drug effects
  • Cell Movement / physiology*
  • Humans
  • Materials Testing
  • Mouth Mucosa / cytology*
  • Mouth Mucosa / drug effects
  • Mouth Mucosa / physiology*
  • Nanoparticles / administration & dosage*
  • Tensile Strength / physiology