Structure modeling using genetically engineered crosslinking

Cell. 2013 Dec 5;155(6):1207-8. doi: 10.1016/j.cell.2013.11.018.

Abstract

Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Models, Molecular*
  • Receptors, Corticotropin-Releasing Hormone / chemistry*
  • Receptors, Corticotropin-Releasing Hormone / metabolism*
  • Urocortins / chemistry*
  • Urocortins / metabolism*

Substances

  • Receptors, Corticotropin-Releasing Hormone
  • UCN1 protein, human
  • Urocortins
  • CRF receptor type 1