Noncanonical Wnt comes of age in hematopoietic stem cells

Cell Stem Cell. 2013 Dec 5;13(6):642-3. doi: 10.1016/j.stem.2013.11.009.


Understanding molecular mechanisms of aging is crucial in efforts to reverse it. In a recent issue of Nature, Florian et al. (2013) report that increasing levels of noncanonical Wnt signaling accompany hematopoietic stem cell (HSC) aging, which can be modulated to functionally rejuvenate HSCs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cellular Senescence*
  • Female
  • Hematopoietic Stem Cells / cytology*
  • Male
  • Wnt Signaling Pathway*