[Correlation between ABCC11 gene single nucleotide polymorphism and the incidence of axillary osmidrosis in Chinese Han population]

Yang Sun; Jianhong Long; Yongjie Wang

doi:10.3969/j.issn.1672-7347.2013.11.010

[Correlation between ABCC11 gene single nucleotide polymorphism and the incidence of axillary osmidrosis in Chinese Han population]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Nov;38(11):1141-5. doi: 10.3969/j.issn.1672-7347.2013.11.010.

[Article in Chinese]

Authors

Yang Sun¹, Jianhong Long, Yongjie Wang

Affiliation

¹ Department of Plastics and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

PMID: 24316925
DOI: 10.3969/j.issn.1672-7347.2013.11.010

Abstract

Objective: To explore the relationship between ABCC11 gene single nucleotide polymorphism (SNP) and the incidence of axillary osmidrosis in Chinese Han population.

Methods: The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing.

Results: The detection of the genotype of ABCC11 gene SNP at rs17822931 showed that: 37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype.

Conclusion: SNP in ABCC11 is the genetic cause of axillary osmidrosis. GG or GA leads to axillary osmidrosis, while AA allele presents the absence of axillary osmidrosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP-Binding Cassette Transporters / genetics*
Alleles
Asian People
Axilla
Gene Frequency*
Genotype
Humans
Incidence
Polymorphism, Single Nucleotide*
Sweat Gland Diseases / genetics*

Substances

ABCC11 protein, human
ATP-Binding Cassette Transporters