Neuronal primary cilia: an underappreciated signaling and sensory organelle in the brain

doi:10.1038/npp.2013.203

. 2014 Jan;39(1):244-5.

doi: 10.1038/npp.2013.203.

Neuronal primary cilia: an underappreciated signaling and sensory organelle in the brain

Jill A Green¹, Kirk Mykytyn

Affiliations

PMID: 24317320
PMCID: PMC3857650
DOI: 10.1038/npp.2013.203

Neuronal primary cilia: an underappreciated signaling and sensory organelle in the brain

Jill A Green et al. Neuropsychopharmacology. 2014 Jan.

. 2014 Jan;39(1):244-5.

doi: 10.1038/npp.2013.203.

Authors

Jill A Green¹, Kirk Mykytyn

Affiliation

¹ Wexner Medical Center, Department of Pharmacology, The Ohio State University, Columbus, OH, USA.

PMID: 24317320
PMCID: PMC3857650
DOI: 10.1038/npp.2013.203

No abstract available

PubMed Disclaimer

Figures

**Figure 1**
(a) A schematic of a network of neurons. Primary cilia (red) protrude from the neuronal cell body. (b) A schematic of a neuronal primary cilium. GPCRs selectively localize to the membrane of the cilium where they may reside as monomeric units and/or heteromers. An intraflagellar transport particle that mediates protein trafficking within cilia is indicated in green. (c) A hypothalamic neuron labeled for the ciliary GPCR, melanin-concentrating hormone receptor 1 (Mchr1, green). Scale bar=10 mm.

See this image and copyright information in PMC

Cited by

Primary Cilia: The New Face of Craniofacial Research.
Moore ER. Moore ER. Biomolecules. 2022 Nov 22;12(12):1724. doi: 10.3390/biom12121724. Biomolecules. 2022. PMID: 36551151 Free PMC article. Review.
Primary Cilia in Amacrine Cells in Retinal Development.
Ning K, Sendayen BE, Kowal TJ, Wang B, Jones BW, Hu Y, Sun Y. Ning K, et al. Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):15. doi: 10.1167/iovs.62.9.15. Invest Ophthalmol Vis Sci. 2021. PMID: 34241625 Free PMC article.
Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment.
Gilloteaux J, De Swert K, Suain V, Nicaise C. Gilloteaux J, et al. Int J Mol Sci. 2023 Nov 17;24(22):16448. doi: 10.3390/ijms242216448. Int J Mol Sci. 2023. PMID: 38003639 Free PMC article.
Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex.
Wu JY, Cho SJ, Descant K, Li PH, Shapson-Coe A, Januszewski M, Berger DR, Meyer C, Casingal C, Huda A, Liu J, Ghashghaei T, Brenman M, Jiang M, Scarborough J, Pope A, Jain V, Stein JL, Guo J, Yasuda R, Lichtman JW, Anton ES. Wu JY, et al. Neuron. 2024 Jan 3;112(1):41-55.e3. doi: 10.1016/j.neuron.2023.09.032. Epub 2023 Oct 28. Neuron. 2024. PMID: 37898123 Free PMC article.
Neuron cilia constrain glial regulators to microdomains around distal neurons.
Ray S, Gurung P, Manning RS, Kravchuk A, Singhvi A. Ray S, et al. bioRxiv [Preprint]. 2023 Mar 18:2023.03.18.533255. doi: 10.1101/2023.03.18.533255. bioRxiv. 2023. PMID: 36993507 Free PMC article. Preprint.

See all "Cited by" articles

References

1. Bishop GA, Berbari NF, Lewis J, Mykytyn K. Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J Comp Neurol. 2007;505:562–571. - PubMed
1. Brailov I, Bancila M, Brisorgueil MJ, Miquel MC, Hamon M, Verge D. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res. 2000;872:271–275. - PubMed
1. Green JA, Gu C, Mykytyn K. Heteromerization of ciliary G protein-coupled receptors in the mouse brain. PLoS ONE. 2012;7:e46304. - PMC - PubMed
1. Green JA, Mykytyn K. Neuronal ciliary signaling in homeostasis and disease. Cell Mol Life Sci. 2010;67:3287–3297. - PMC - PubMed
1. Handel M, Schulz S, Stanarius A, Schreff M, Erdtmann-Vourliotis M, Schmidt H, et al. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. 1999;89:909–926. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

[1] Bishop GA, Berbari NF, Lewis J, Mykytyn K. Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J Comp Neurol. 2007;505:562–571. - PubMed

[2] Bishop GA, Berbari NF, Lewis J, Mykytyn K. Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J Comp Neurol. 2007;505:562–571. - PubMed

[3] Brailov I, Bancila M, Brisorgueil MJ, Miquel MC, Hamon M, Verge D. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res. 2000;872:271–275. - PubMed

[4] Brailov I, Bancila M, Brisorgueil MJ, Miquel MC, Hamon M, Verge D. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brain Res. 2000;872:271–275. - PubMed

[5] Green JA, Gu C, Mykytyn K. Heteromerization of ciliary G protein-coupled receptors in the mouse brain. PLoS ONE. 2012;7:e46304. - PMC - PubMed

[6] Green JA, Gu C, Mykytyn K. Heteromerization of ciliary G protein-coupled receptors in the mouse brain. PLoS ONE. 2012;7:e46304. - PMC - PubMed

[7] Green JA, Mykytyn K. Neuronal ciliary signaling in homeostasis and disease. Cell Mol Life Sci. 2010;67:3287–3297. - PMC - PubMed

[8] Green JA, Mykytyn K. Neuronal ciliary signaling in homeostasis and disease. Cell Mol Life Sci. 2010;67:3287–3297. - PMC - PubMed

[9] Handel M, Schulz S, Stanarius A, Schreff M, Erdtmann-Vourliotis M, Schmidt H, et al. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. 1999;89:909–926. - PubMed

[10] Handel M, Schulz S, Stanarius A, Schreff M, Erdtmann-Vourliotis M, Schmidt H, et al. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience. 1999;89:909–926. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Neuronal primary cilia: an underappreciated signaling and sensory organelle in the brain

Affiliation

Neuronal primary cilia: an underappreciated signaling and sensory organelle in the brain

Authors

Affiliation

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources