Effects of Aronia melanocarpa constituents on biofilm formation of Escherichia coli and Bacillus cereus

Molecules. 2013 Dec 5;18(12):14989-99. doi: 10.3390/molecules181214989.


Many bacteria growing on surfaces form biofilms. Adaptive and genetic changes of the microorganisms in this structure make them resistant to antimicrobial agents. Biofilm-forming organisms on medical devices can pose serious threats to human health. Thus, there is a need for novel prevention and treatment strategies. This study aimed to evaluate the ability of Aronia melanocarpa extracts, subfractions and compounds to prevent biofilm formation and to inhibit bacterial growth of Escherichia coli and Bacillus cereus in vitro. It was found that several aronia substances possessed anti-biofilm activity, however, they were not toxic to the species screened. This non-toxic inhibition may confer a lower potential for resistance development compared to conventional antimicrobials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Bacillus cereus / drug effects*
  • Bacillus cereus / physiology
  • Biofilms / drug effects*
  • Escherichia coli / drug effects*
  • Escherichia coli / physiology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Photinia / chemistry*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*


  • Anti-Bacterial Agents
  • Plant Extracts