Quality of life assessed with EQ-5D in patients undergoing glioma surgery: what is the responsiveness and minimal clinically important difference?

Qual Life Res. 2014 Jun;23(5):1427-34. doi: 10.1007/s11136-013-0593-4. Epub 2013 Dec 7.


Purpose: To evaluate the responsiveness of EQ-5D 3L in patients undergoing intracranial glioma surgery and estimate the minimal clinically important difference (MCID).

Materials and methods: EQ-5D 3L index values from 164 patients who underwent glioma surgery in the period 2007-2012 were analysed. Responsiveness and MCID were estimated using a combination of distribution-based and anchor-based methods. Karnofsky performance status served as an anchor.

Results: Patients who improved functionally did not report significantly higher EQ-5D 3L scores post operatively with a standardized response mean (SRM) of 0.04 (p = 0.13). Patients who deteriorated functionally reported significantly lower EQ-5D 3L scores post operatively with a SRM of 0.72 (p < 0.001). With different approaches, we determined a range of MCID values from 0.13 to 0.15.

Conclusions: EQ-5D 3L is responsive to changes when glioma patients are deteriorating functionally after surgery but not responsive when the patients are improving. The MCID values for EQ-5D 3L in glioma surgery seem higher than reported MCID values for other types of cancers.

Publication types

  • Validation Study

MeSH terms

  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / psychology*
  • Brain Neoplasms / surgery
  • Chemotherapy, Adjuvant
  • Cross-Sectional Studies
  • Drug-Related Side Effects and Adverse Reactions
  • Female
  • Glioma / drug therapy
  • Glioma / psychology*
  • Glioma / surgery
  • Health Status Indicators
  • Humans
  • Karnofsky Performance Status / statistics & numerical data
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neoplasm Grading / psychology
  • Norway
  • Postoperative Period
  • Prospective Studies
  • Quality of Life / psychology*
  • Sickness Impact Profile
  • Surveys and Questionnaires / standards*
  • Time Factors
  • Treatment Outcome
  • Visual Analog Scale