Poly(vinylidene-trifluoroethylene)/barium titanate composite for in vivo support of bone formation

J Biomater Appl. 2014 Jul;29(1):104-12. doi: 10.1177/0885328213515735. Epub 2013 Dec 6.

Abstract

In this study, we evaluated the effect of poly(vinylidene fluoride-trifluoroethylene)/barium titanate (P(VDF-TrFE)/BT) membrane on in vivo bone formation. Rat calvarial bone defects were implanted with P(VDF-TrFE)/BT and polytetrafluoroethylene (PTFE) membranes, and at 4 and 8 weeks, histomorphometric and gene expression analyses were performed. A higher amount of bone formation was noticed on P(VDF-TrFE)/BT compared with PTFE. The gene expression of RUNX2, bone sialoprotein, osteocalcin, receptor activator of nuclear factor-kappa B ligand, and osteoprotegerin indicates that P(VDF-TrFE)/BT favored the osteoblast differentiation compared with PTFE. These results evidenced the benefits of using P(VDF-TrFE)/BT to promote new bone formation, which may represent a promising alternative to be employed in guided bone regeneration.

Keywords: Bone; ceramic; guided bone regeneration; membrane; osteoblast; polymer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Barium Compounds / chemistry
  • Biocompatible Materials / chemistry
  • Bone Regeneration*
  • Bone Substitutes / chemistry
  • Gene Expression
  • Guided Tissue Regeneration / methods*
  • Hydrocarbons, Fluorinated / chemistry
  • Imaging, Three-Dimensional
  • Materials Testing
  • Membranes, Artificial
  • Osteoblasts / cytology
  • Osteoblasts / metabolism
  • Rats
  • Rats, Wistar
  • Skull / injuries
  • Skull / metabolism
  • Skull / pathology
  • Titanium / chemistry
  • Vinyl Compounds / chemistry
  • X-Ray Microtomography

Substances

  • Barium Compounds
  • Biocompatible Materials
  • Bone Substitutes
  • Hydrocarbons, Fluorinated
  • Membranes, Artificial
  • Vinyl Compounds
  • poly(vinylidenefluoride-trifluoroethylene)
  • barium titanate(IV)
  • Titanium