Anal fissures in infants may be a pathognomonic sign of infants with cow's milk allergy

J Med Assoc Thai. 2013 Jul;96(7):786-9.


Objective: To study the association between analfissures and cow's milk allergy (CMA) in infants. METHODS AND METHOD: In a prospective study, 72 confirmed cases of CMA in infants were examined for anal fissure by pediatricians with five years' experience. A positive finding was defined as when an anal fissure was detected by at least two out of three examiners.

Results: Of infants with CMA with and without gastrointestinal GI symptoms, 79% and 83% had anal fissures, respectively The prevalence of anal fissure in these infants is significantly higher than in normal infants.

Conclusion: Anal fissure may be a pathognomonic sign of cow's milk allergy in infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Female
  • Fissure in Ano / epidemiology*
  • Fissure in Ano / pathology
  • Humans
  • Infant
  • Male
  • Milk Hypersensitivity / complications*
  • Milk Hypersensitivity / pathology*
  • Prevalence
  • Prospective Studies
  • Risk Factors