[Need for rheologically active, vasoactive and metabolically active substances in the initial treatment of acute acoustic trauma]

HNO. 1986 Oct;34(10):424-8.
[Article in German]


Two rheologically active and 8 vasoactive and metabolically active substances were compared in eight independent studies, some of which were randomised and double blind, on 400 patients who had suffered acute acoustic trauma. The control group was given saline. Spontaneous recovery was excluded as far as possible. The following substances were tested: Dextran 40, hydroxyethyl starch 40/0.5, naftidrofurylhydrogenoxalate, Vinpocetin, betahistine, pentoxifylline, flunaricine, Regeneresen AU 4 and 0.9% saline. All groups showed superior results to the control group in both long-term and short-term tests with respect to hearing gain and tinnitis improvement. The rheologically effective substances showed no statistically significant variations. None of the vasoactive or metabolically active substances used as adjunctive therapy improved the results achieved with rheologically effective substances alone. These results demonstrate that acute acoustic trauma can be most effectively treated by rheologically active substances; vasoactive and metabolically active substances are unnecessary. Hyperbaric oxygenation is advantageous as an adjunctive therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Betahistine / therapeutic use
  • Dextrans / therapeutic use
  • Drug Therapy, Combination
  • First Aid*
  • Flunarizine / therapeutic use
  • Hearing Loss, Noise-Induced / drug therapy*
  • Humans
  • Hydroxyethyl Starch Derivatives / therapeutic use
  • Male
  • Meniere Disease / drug therapy
  • Military Personnel*
  • Nafronyl / therapeutic use
  • Pentoxifylline / therapeutic use
  • Rheology*
  • Sodium Chloride / therapeutic use
  • Tinnitus / drug therapy
  • Vasodilator Agents / therapeutic use*
  • Vinca Alkaloids / therapeutic use


  • Dextrans
  • Hydroxyethyl Starch Derivatives
  • Vasodilator Agents
  • Vinca Alkaloids
  • Nafronyl
  • Sodium Chloride
  • vinpocetine
  • Flunarizine
  • Pentoxifylline
  • Betahistine