On best practices: the Institute of Medicine scheme for developing, validating, and demonstrating clinical utility of omics-based diagnostic and predictive tests

Proteomics Clin Appl. 2013 Dec;7(11-12):748-55. doi: 10.1002/prca.201300041.


The Institute of Medicine of the US National Academy of Sciences issued a major report in 2012 that provides important guidance for the proteomics community for credible and transparent development of all kinds of omics-based diagnostic and prognostic tests. The key elements are summarized here to provide a compass that can guide the studies emerging from many laboratories as reported in this special issue of Proteomics Clinical Applications on "Diagnostic Proteomics."

Keywords: Diagnostics; Institute of Medicine; Omics; Tests.

MeSH terms

  • Humans
  • National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division
  • Proteomics / methods*
  • United States