Adoptive immunotherapy for cancer

Immunol Rev. 2014 Jan;257(1):14-38. doi: 10.1111/imr.12136.


Recent clinical success has underscored the potential for immunotherapy based on the adoptive cell transfer (ACT) of engineered T lymphocytes to mediate dramatic, potent, and durable clinical responses. This success has led to the broader evaluation of engineered T-lymphocyte-based adoptive cell therapy to treat a broad range of malignancies. In this review, we summarize concepts, successes, and challenges for the broader development of this promising field, focusing principally on lessons gleaned from immunological principles and clinical thought. We present ACT in the context of integrating T-cell and tumor biology and the broader systemic immune response.

Keywords: adoptive cell therapy; cancer; chimeric antigen receptor; immune modulation; immunotherapy; tumor microenvironment.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adoptive Transfer / methods
  • Animals
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immunotherapy, Adoptive* / history
  • Immunotherapy, Adoptive* / methods
  • Immunotherapy, Adoptive* / trends
  • Neoplasms / immunology*
  • Neoplasms / therapy*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism