Total adiponectin, but not inflammatory markers C-reactive protein, tumor necrosis factor-α, interluekin-6 and monocyte chemoattractant protein-1, correlates with increasing glucose intolerance in pregnant Chinese-Americans

J Diabetes. 2014 Jul;6(4):360-8. doi: 10.1111/1753-0407.12114. Epub 2014 Feb 26.


Background: Elevated insulin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels and decreased high molecular weight adiponectin (HMW-APN) levels have been reported in Caucasians with gestational diabetes mellitus (GDM). No similar studies have been performed in Chinese women.

Methods: Serum samples were obtained 1 h after a 50-g glucose challenge test (1HGCT) from Chinese-American women at 24-28 gestational weeks and total adiponectin (T-APN), HMW-APN, CRP, TNF-α, IL-6, and MCP-1 concentrations were measured. Correlation coefficients for glucose (1HGCT), HbA1c, insulin, and body mass index (BMI) were calculated against T-APN, HMW-APN, CRP, TNF-α, IL-6, and MCP-1. Significant P-values were determined using Bonferroni adjustments.

Results: Women with GDM had higher insulin and 1HGCT and lower T-APN. In addition, T-APN was lower in non-GDM subjects who had 1HGCT ≥135 mg/dL with no abnormal or one abnormal glucose value on the 3-h oral glucose tolerance test. There were no significant differences in HMW-APN and inflammatory marker levels between non-GDM and GDM groups. There were negative correlations between T-APN and 1HGCT, insulin, BMI, and HbA1c, as well as between HMW-APN and 1HGCT, insulin, and BMI. No significant correlations were observed between 1HGCT, HbA1c, insulin, or BMI and CRP, TNF-α, IL-6, or MCP-1.

Conclusions: T-APN is reduced in Chinese women with GDM and those without GDM but with evidence of glucose intolerance. Unlike results reported for Caucasians, Chinese-American women with GDM do not exhibit elevated levels of CRP, TNF-α, IL-6, or MCP-1, possibly because Chinese women are relatively leaner compared with Caucasians.

Keywords: Chinese pregnant women; HMW-adiponectin; T-adiponectin; gestational diabetes; glucose intolerance; inflammatory markers; 华裔妊娠妇女,妊娠糖尿病,葡萄糖耐量,HMW-脂联素,炎症标志物,T-脂联素.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adolescent
  • Adult
  • Asian
  • Biomarkers / blood*
  • Blood Glucose / analysis
  • C-Reactive Protein / metabolism*
  • Chemokine CCL2 / blood*
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diagnosis*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Glucose Intolerance / blood
  • Glucose Intolerance / diagnosis*
  • Glycated Hemoglobin / analysis
  • Humans
  • Interleukin-6 / blood*
  • Pregnancy
  • Prognosis
  • Tumor Necrosis Factor-alpha / blood*
  • Young Adult


  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • CCL2 protein, human
  • Chemokine CCL2
  • Glycated Hemoglobin A
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein