Determination of neuron specific enolase in amniotic fluid and maternal serum for the prenatal diagnosis of fetal neural tube defects

Clin Chim Acta. 1987 Jan 15;162(1):101-4. doi: 10.1016/0009-8981(87)90238-5.

Abstract

Maternal serum neuron-specific enolase was tested as a marker for fetal nural tube defect. In around 50% of pregnancies with affected fetus the level was elevated. The increase was also found in the amniotic fluids. Normal fetal serum did not display elevation of neuron-specific enolase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / blood
  • Amniotic Fluid / enzymology*
  • Female
  • Fetal Diseases / diagnosis*
  • Gestational Age
  • Humans
  • Neural Tube Defects / diagnosis*
  • Phosphopyruvate Hydratase / analysis*
  • Pregnancy
  • Prenatal Diagnosis*
  • alpha-Fetoproteins / analysis

Substances

  • alpha-Fetoproteins
  • Acetylcholinesterase
  • Phosphopyruvate Hydratase