Depression and use of antidepressants in Swedish nursing homes: a 12-month follow-up study

Int Psychogeriatr. 2014 Apr;26(4):669-75. doi: 10.1017/S1041610213002354. Epub 2013 Dec 16.


Background: The prescription of antidepressants in nursing homes has increased markedly since the introduction of SSRIs, while at the same time depressive symptoms often go unrecognized and untreated. The aim of this study was to examine whether depression among residents in nursing homes is treated adequately.

Methods: A sample of 429 participants from 11 Swedish nursing homes was selected and was assessed with the Cornell Scale for Depression in Dementia (CSDD) and using medical records and drug prescription data. For 256 participants a follow-up assessment was performed after 12 months.

Results: The prevalence of depression, according to medical records, was 9.1%, and the prevalence of CSDD score of ≥8 was 7.5%. Depression persisted in more than 50% of cases at the 12-month follow-up. Antidepressants were prescribed to 33% of the participants without a depression diagnosis or with a CSDD score of <8. 46.2% of all participants were prescribed antidepressants. 14% of the participants without a depression diagnosis or with a CSDD score of <8 had psychotropic polypharmacy. 15.2% of all participants had psychotropic polypharmacy, which persisted at the 12-month follow-up in three-quarters of cases.

Conclusion: The prescription of antidepressants in frail elderly individuals is extensive and may be without clear indication. The clinical implication is that there is a need for systematic drug reviews at nursing homes, paying special attention to the subjects which are on antidepressants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antidepressive Agents / therapeutic use*
  • Dementia / drug therapy
  • Dementia / epidemiology
  • Depression / drug therapy*
  • Depression / epidemiology
  • Depressive Disorder / drug therapy
  • Depressive Disorder / epidemiology
  • Drug Prescriptions / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Frail Elderly
  • Homes for the Aged
  • Humans
  • Male
  • Middle Aged
  • Nursing Homes / statistics & numerical data*
  • Polypharmacy
  • Prevalence
  • Sweden / epidemiology


  • Antidepressive Agents