Streptococcus pyogenes escapes from autophagy

Cell Host Microbe. 2013 Dec 11;14(6):604-6. doi: 10.1016/j.chom.2013.11.012.

Abstract

Autophagy is important for innate defense against intracellular bacteria, such as Group A Streptococcus (GAS). In this issue of Cell Host & Microbe, Barnett et al. (2013) demonstrate that the globally disseminated serotype M1T1 clone of GAS can evade autophagy via streptococcal cysteine protease SpeB-mediated degradation of ubiquitin-LC3 adaptor proteins.

Publication types

  • Comment

MeSH terms

  • Autophagy*
  • Host-Pathogen Interactions*
  • Humans
  • Immune Evasion*
  • Streptococcus pyogenes / immunology*
  • Streptococcus pyogenes / physiology*