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. 2013 Dec 11;14(6):604-6.
doi: 10.1016/j.chom.2013.11.012.

Streptococcus Pyogenes Escapes From Autophagy


Streptococcus Pyogenes Escapes From Autophagy

Ichiro Nakagawa. Cell Host Microbe. .


Autophagy is important for innate defense against intracellular bacteria, such as Group A Streptococcus (GAS). In this issue of Cell Host & Microbe, Barnett et al. (2013) demonstrate that the globally disseminated serotype M1T1 clone of GAS can evade autophagy via streptococcal cysteine protease SpeB-mediated degradation of ubiquitin-LC3 adaptor proteins.

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