Body fluid biomarkers in multiple sclerosis

Lancet Neurol. 2014 Jan;13(1):113-26. doi: 10.1016/S1474-4422(13)70233-3.


Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological disorders. The study of multiple sclerosis can benefit from the use of biomarkers because of the disease's inherent heterogeneity. Biomarkers in multiple sclerosis might assist with diagnosis, prediction of disease course, or identification of response outcome to treatments. Despite the need for biomarkers and extensive research to identify them, validation and clinical application of biomarkers is still an unmet need in multiple sclerosis, and large gaps remain between exploratory biomarkers proposed in many studies, validated biomarkers, and biomarkers that are integrated into routine clinical practice.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Biomarkers / cerebrospinal fluid
  • Body Fluids / metabolism*
  • Humans
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnosis


  • Biomarkers