Ischemic heart disease in systemic inflammatory diseases. An appraisal

Int J Cardiol. 2014 Jan 1;170(3):286-90. doi: 10.1016/j.ijcard.2013.11.048. Epub 2013 Nov 25.


Systemic inflammatory diseases are inflammatory syndromes that are associated with increased cardiovascular morbidity and mortality. The link between inflammatory and cardiovascular diseases can be attributed to coexistence of classical risk factors and of inflammatory mechanisms activated in systemic inflammatory diseases and involving the immune system. Yet, clinical implications of these findings are not entirely clear and deeper knowledge and awareness of cardiac involvement in inflammatory diseases are necessary. The aims of this review are to summarize cardiac involvement in systemic inflammatory diseases and to identify areas where evidence is currently lacking that deserve further investigation in the future.

Keywords: Atherosclerosis; Coronary artery disease; Immune system; Systemic inflammatory disease.

Publication types

  • Review

MeSH terms

  • Atherosclerosis / epidemiology
  • Atherosclerosis / immunology*
  • Atherosclerosis / physiopathology
  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / physiopathology
  • Coronary Artery Disease / epidemiology
  • Coronary Artery Disease / immunology*
  • Coronary Artery Disease / physiopathology
  • Humans
  • Myocardial Ischemia / epidemiology
  • Myocardial Ischemia / immunology*
  • Myocardial Ischemia / physiopathology
  • Rheumatic Diseases / epidemiology
  • Rheumatic Diseases / immunology*
  • Rheumatic Diseases / physiopathology
  • Risk Factors