cGAS dimerization entangles DNA recognition

Philip J Kranzusch; Russell E Vance

doi:10.1016/j.immuni.2013.11.012

cGAS dimerization entangles DNA recognition

Immunity. 2013 Dec 12;39(6):992-4. doi: 10.1016/j.immuni.2013.11.012.

Authors

Philip J Kranzusch¹, Russell E Vance²

Affiliations

¹ Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rvance@berkeley.edu.

PMID: 24332024
DOI: 10.1016/j.immuni.2013.11.012

Abstract

Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
DNA / metabolism*
Humans
Models, Molecular*
Nucleotidyltransferases / chemistry*
Nucleotidyltransferases / metabolism*

Substances

DNA
Nucleotidyltransferases
cGAS protein, mouse

Grants and funding

Howard Hughes Medical Institute/United States