IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis

Clin Imaging. 2014 Mar-Apr;38(2):195-8. doi: 10.1016/j.clinimag.2013.11.002. Epub 2013 Nov 12.

Abstract

Background: IgG4-related systemic disease (IgG4-RSD) is a recently recognised fibroinflammatory condition, characterized by a tissue infiltration and/or enlargement and typical histopathological findings.

Methods and results: We report on a 73-year-old male with bilateral preauricular swelling and a remote history of unexplained systemic disease. Magnetic resonance imaging showed enlargement of all major salivary glands and cervical lymph node due to a tissue infiltration with marked enhancement and restricted diffusion. Elevated serum IgG4 levels and histopathological findings on an excisional lymph node biopsy were consistent with IgG4-RSD.

Conclusion: Magnetic resonance imaging seems to be a useful tool to support the diagnosis of IgG4-related systemic disease of salivary glands.

Keywords: Chronic sclerosing sialadenitis; IgG4-related systemic disease; Küttner tumor; Lymphadenitis; MRI; Parotid gland.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology*
  • Biopsy
  • Humans
  • Immunoglobulin G / immunology*
  • Inflammation
  • Lymph Nodes / pathology
  • Lymphadenitis / immunology
  • Lymphadenitis / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Parotid Gland / pathology*
  • Salivary Glands / pathology
  • Sialadenitis / immunology
  • Sialadenitis / pathology*
  • Submandibular Gland / pathology*
  • Treatment Outcome

Substances

  • Immunoglobulin G