Renal replacement therapy due to type 1 diabetes; time trends during 1995-2010--a Swedish population based register study

J Diabetes Complications. 2014 Mar-Apr;28(2):152-5. doi: 10.1016/j.jdiacomp.2013.10.007. Epub 2013 Oct 22.


Background: End stage renal disease (ESRD), is the most severe complication of diabetes mellitus. This population-based study analysed time trends for start of renal replacement therapy (RRT) due to type 1 diabetes compared to type 2 diabetes and other diagnoses.

Material and methods: We used data on patients who were registered 1995-2010 in the Swedish Renal Registry, a nationwide register covering 95 % of all patients with uraemia. The patients were analysed according to their original kidney disease. The incidence was analysed by calendar year, age at start of RRT and gender.

Results: Of 17389 patients who were registered, 1833 had type 1 diabetes; 65% were men. The mean age at onset of RRT for patients with type 1 diabetes was 52.8 years which increased by more than 3 years over the studied period. The number of patients in need of RRT due to type 1 diabetes decreased, while RRT due to type 2 diabetes increased during the period studied.

Conclusions: The overall incidence of RRT in Sweden is rather constant over the years but the need for RRT in type 1 diabetes patients decreased and patients with type 1 diabetes tend to become older at onset of RRT.

Keywords: Diabetes mellitus; Incidence; Nephropathy; Renal replacement therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / therapy*
  • Diabetic Nephropathies / epidemiology
  • Diabetic Nephropathies / therapy*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Registries / statistics & numerical data
  • Renal Replacement Therapy* / statistics & numerical data
  • Sweden / epidemiology
  • Young Adult