Phylogeographic Diversity of Pathogenic and Non-Pathogenic Hantaviruses in Slovenia

Viruses. 2013 Dec 10;5(12):3071-87. doi: 10.3390/v5123071.

Abstract

Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus-Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus),M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava-Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cluster Analysis
  • Genetic Variation*
  • Hantavirus / classification*
  • Hantavirus / genetics
  • Hantavirus / isolation & purification*
  • Hantavirus Infections / epidemiology
  • Hantavirus Infections / veterinary*
  • Hantavirus Infections / virology*
  • Humans
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeography*
  • RNA, Viral / genetics
  • Rodentia
  • Sequence Analysis, DNA
  • Slovenia / epidemiology

Substances

  • RNA, Viral

Associated data

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