The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

Nature. 1987 Jan 22-28;325(6102):321-6. doi: 10.1038/325321a0.

Abstract

Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chick Embryo
  • Electric Conductivity
  • GTP-Binding Proteins / physiology*
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Guanosine Triphosphate / analogs & derivatives
  • Guanosine Triphosphate / pharmacology
  • Guanylyl Imidodiphosphate / pharmacology
  • Heart / physiology*
  • In Vitro Techniques
  • Ion Channels / physiology*
  • Macromolecular Substances
  • Magnesium / pharmacology
  • Potassium / physiology*
  • Receptors, Muscarinic / physiology*
  • Structure-Activity Relationship
  • Thionucleotides / pharmacology

Substances

  • Ion Channels
  • Macromolecular Substances
  • Receptors, Muscarinic
  • Thionucleotides
  • Guanylyl Imidodiphosphate
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Guanosine Triphosphate
  • GTP-Binding Proteins
  • Magnesium
  • Potassium