Gene expression scaled by distance to the genome replication site

Mol Biosyst. 2014 Mar 4;10(3):375-9. doi: 10.1039/c3mb70254e. Epub 2013 Dec 12.


A simple mode of gene expression scaled by the distance from the chromosomal location of the gene to the genome replication site oriC was determined. The common formula representing the effect of genomic position on expression capacity not only supports the multifork replication model but also provides a base correlation for theoretical simulation and synthetic constructs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Bacterial
  • DNA Replication*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Bacterial
  • Gene Expression*
  • Gene Order
  • Genome*
  • Proteome
  • Replication Origin*
  • Transcriptome
  • Transgenes


  • Proteome