Circulation of classical swine influenza virus in Europe between the wars?

Arch Virol. 2014 Jun;159(6):1467-73. doi: 10.1007/s00705-013-1950-x. Epub 2013 Dec 15.


The complete genomes of two swine influenza viruses from England were sequenced. Phylogenetic analysis revealed classical swine H1N1 viruses, one of which, A/swine/London, is closely related to virus strains of the early 1930s. Both strains are also antigenically related to A/swine/Iowa/15/1930, the strain originally isolated by Richard Shope. The source of A/swine/London is unknown, but its relationship to early classical swine influenza viruses suggests that the emergence of these viruses in Europe has to be antedated by 15-20 years.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / genetics
  • England
  • Evolution, Molecular
  • History, 20th Century
  • Humans
  • Influenza A Virus, H1N1 Subtype / classification*
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / epidemiology*
  • Influenza, Human / history
  • Influenza, Human / virology*
  • Orthomyxoviridae Infections / epidemiology*
  • Orthomyxoviridae Infections / history
  • Orthomyxoviridae Infections / virology*
  • Swine
  • Swine Diseases / epidemiology*
  • Swine Diseases / history
  • Swine Diseases / virology*


  • Antigens, Viral