Atopic keratoconjunctivitis: A review

J Am Acad Dermatol. 2014 Mar;70(3):569-75. doi: 10.1016/j.jaad.2013.10.036. Epub 2013 Dec 15.

Abstract

Atopic keratoconjunctivitis is a chronic noninfectious inflammatory condition and is one of the most severe ophthalmic complications associated with atopic dermatitis. It requires prompt and effective treatment to prevent permanent vision loss. Complications of atopic keratoconjunctivitis include cataracts, keratoconus, infectious keratitis, blepharitis, tear dysfunction, and steroid-induced glaucoma. All treatment for atopic keratoconjunctivitis should be managed in conjunction with an ophthalmologist, and immediate referral is indicated when there is moderate to severe irritation, increased redness, discharge, or any visual symptoms. Treatment options include a combination of mast cell inhibitors, antihistamines, corticosteroids, and calcineurin inhibitors.

Keywords: atopic dermatitis; atopic keratoconjunctivitis; conjunctiva; cornea; keratoconus; ocular; sight threatening.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Calcineurin Inhibitors
  • Cataract / etiology
  • Cataract / prevention & control*
  • Conjunctivitis, Allergic / drug therapy
  • Conjunctivitis, Allergic / etiology
  • Conjunctivitis, Allergic / physiopathology
  • Dermatitis, Atopic / complications*
  • Dermatitis, Atopic / diagnosis
  • Dermatitis, Atopic / therapy
  • Drug Therapy, Combination
  • Early Diagnosis
  • Female
  • Histamine Antagonists / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Keratoconjunctivitis / drug therapy*
  • Keratoconjunctivitis / etiology*
  • Keratoconjunctivitis / physiopathology
  • Male
  • Prognosis
  • Referral and Consultation
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome
  • Vision Disorders / etiology
  • Vision Disorders / prevention & control*

Substances

  • Adrenal Cortex Hormones
  • Calcineurin Inhibitors
  • Histamine Antagonists
  • Immunosuppressive Agents