Regenerative medicine: transdifferentiation in vivo

Cell Res. 2014 Feb;24(2):141-2. doi: 10.1038/cr.2013.165. Epub 2013 Dec 17.


A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.

MeSH terms

  • Animals
  • Cell Transdifferentiation
  • Cellular Reprogramming
  • Genetic Vectors / genetics
  • Genetic Vectors / metabolism
  • Mice
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism
  • Pluripotent Stem Cells / transplantation
  • Regenerative Medicine*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism


  • Transcription Factors