Phytochemical and pharmacological studies on Radix Angelica sinensis

Chin J Nat Med. 2013 Nov;11(6):577-87. doi: 10.1016/S1875-5364(13)60067-9.


The roots of Angelica sinensis (RAS), are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women's diseases. It has also been widely marketed as health food for women's care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregulatory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.

Keywords: Chemical constituents; Clinical applications; Interactions; Pharmacological effect; Radix Angelica Sinensis; Toxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angelica sinensis / adverse effects
  • Angelica sinensis / chemistry*
  • Animals
  • Drugs, Chinese Herbal / adverse effects
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology*
  • Humans
  • Phytotherapy
  • Plant Roots / chemistry


  • Drugs, Chinese Herbal
  • angelicae sinensis extract