Qualitative analysis of the humoral immune response to the "a" determinant of HBs antigen after inoculation with plasma-derived or recombinant vaccine

J Med Virol. 1987 Feb;21(2):155-60. doi: 10.1002/jmv.1890210207.


Competitive inhibition assays using monoclonal antibodies reacting with defined sequence of the "a" determinant of hepatitis B surface antigen (HBsAg) indicate that the humoral response to plasma-derived and recombinant HBsAg vaccine is similar in quantitative and qualitative terms. Both vaccines evoke an antibody response to the RFHBs 1 epitope, which is known in animal experiments to be protective.

MeSH terms

  • Adolescent
  • Adult
  • Epitopes / immunology
  • Hepatitis B Antibodies / analysis
  • Hepatitis B Antibodies / biosynthesis*
  • Hepatitis B Surface Antigens / immunology*
  • Hepatitis B Vaccines
  • Humans
  • Male
  • Radioimmunoassay
  • Recombinant Proteins / immunology
  • Viral Hepatitis Vaccines / immunology*


  • Epitopes
  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines
  • Recombinant Proteins
  • Viral Hepatitis Vaccines