Photo-crosslinkable PEG-based microribbons for forming 3D macroporous scaffolds with decoupled niche properties

Adv Mater. 2014 Mar 19;26(11):1757-62. doi: 10.1002/adma.201304805. Epub 2013 Dec 17.

Abstract

PEG-based microribbons are designed and fabricated as building blocks for constructing a 3D cell niche with independently tunable biochemical, mechanical, and topographical cues. This platform supports direct cell encapsulation, allows spatial patterning of biochemical cues, and may provide a valuable tool for facilitating the analyses of how interactive niche signaling regulates cell fate in three dimensions.

Keywords: biomedical applications; microribbons; scaffolds; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / cytology
  • Adipose Tissue / physiology
  • Biocompatible Materials / chemistry*
  • Cell Movement / physiology
  • Cell Proliferation
  • Cystine / chemistry
  • Elasticity
  • Humans
  • Hydrogels / chemistry*
  • Microscopy, Confocal
  • Microtechnology
  • Peptides / metabolism
  • Polyethylene Glycols / chemistry*
  • Porosity
  • Signal Transduction
  • Stromal Cells / cytology
  • Stromal Cells / physiology
  • Surface Properties
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials
  • Hydrogels
  • Peptides
  • Polyethylene Glycols
  • Cystine