Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;2013:538673.
doi: 10.1155/2013/538673. Epub 2013 Nov 20.

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides Farinae Allergen in NC/Nga Mice

Free PMC article

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides Farinae Allergen in NC/Nga Mice

Rosa Mistica C Ignacio et al. Evid Based Complement Alternat Med. .
Free PMC article


Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF- α ), Th1 (IFN- γ , IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF- α , IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group. The results suggest that HW affects allergic contact dermatitis through modulation of Th1 and Th2 responses in NC/Nga mice. This is the first note on the drinking effect of HW on AD, clinically implying a promising potential remedy for treatment of AD.


Figure 1
Figure 1
Effect of drinking hydrogen water (HW) on proinflammatory, T helper (Th) 1, and Th2 cytokines. Mice administered with HW significantly decreased Dermatophargoides farinae extract had (DfE-)induced cytokines IL-10 (a), GM-CSF (b), IL-12p70 (c) and TNF-α (d) levels. IL-2 (e) and IL-4 (f) did not differ significantly between HW and purified water (PW) groups. Data are mean ± SD, n = 12. *P < 0.05, **P < 0.01, and ***P < 0.001 indicate significant differences tested with ANOVA. Tukey's test was used for post hoc tests.

Similar articles

See all similar articles

Cited by 6 articles

See all "Cited by" articles


    1. Auriemma M, Vianale G, Amerio P, Reale M. Cytokines and T cells in atopic dermatitis. European Cytokine Network. 2013;24(1):37–44. - PubMed
    1. Schneider L, Tilles S, Lio P, et al. Atopic dermatitis: a practice parameter update 2012. The Journal of Allergy and Clinical Immunology. 2013;131(2):295–299. - PubMed
    1. Udompataikul M, Limpa-o-vart D. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study. Journal of Drugs in Dermatology. 2012;11(3):366–374. - PubMed
    1. Leung DYM, Bieber T. Atopic dermatitis. The Lancet. 2003;361(9352):151–160. - PubMed
    1. Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. The Journal of Clinical Investigation. 2004;113(5):651–657. - PMC - PubMed

LinkOut - more resources