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. 2014 Jan 3;13(1):107-13.
doi: 10.1021/pr400884c. Epub 2013 Dec 18.

MOPED Enables Discoveries Through Consistently Processed Proteomics Data

Free PMC article

MOPED Enables Discoveries Through Consistently Processed Proteomics Data

Roger Higdon et al. J Proteome Res. .
Free PMC article

Abstract

The Model Organism Protein Expression Database (MOPED, http://moped.proteinspire.org) is an expanding proteomics resource to enable biological and biomedical discoveries. MOPED aggregates simple, standardized and consistently processed summaries of protein expression and metadata from proteomics (mass spectrometry) experiments from human and model organisms (mouse, worm, and yeast). The latest version of MOPED adds new estimates of protein abundance and concentration as well as relative (differential) expression data. MOPED provides a new updated query interface that allows users to explore information by organism, tissue, localization, condition, experiment, or keyword. MOPED supports the Human Proteome Project's efforts to generate chromosome- and diseases-specific proteomes by providing links from proteins to chromosome and disease information as well as many complementary resources. MOPED supports a new omics metadata checklist to harmonize data integration, analysis, and use. MOPED's development is driven by the user community, which spans 90 countries and guides future development that will transform MOPED into a multiomics resource. MOPED encourages users to submit data in a simple format. They can use the metadata checklist to generate a data publication for this submission. As a result, MOPED will provide even greater insights into complex biological processes and systems and enable deeper and more comprehensive biological and biomedical discoveries.

Figures

Figure 1
Figure 1
MOPED Absolute Expression Query Results page. A Query by Organism (Mouse), Tissue (Lung), and Localization (Mitochondrion). Results table not fully shown. Also, shown is a chord plot detailing the proteins in MOPED broken down by tissue, localization, condition and experiment.
Figure 2
Figure 2
Individual protein page displaying links to outside resources and pathways and providing a comparison of absolute and relative expression across different proteomics experiments. The page also presents visualization of expression grouped by tissues comparing different experiments and conditions.

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