Metal-free synthesis of ynones from acyl chlorides and potassium alkynyltrifluoroborate salts

Org Lett. 2014 Jan 17;16(2):488-91. doi: 10.1021/ol403370t. Epub 2013 Dec 18.

Abstract

A straightforward method for the preparation of ynones from acyl chlorides and potassium alkynyltrifluoroborate salts has been developed. The one-pot reaction proceeds rapidly in the presence of a Lewis acid without exclusion of air and moisture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis*
  • Alkynes / chemistry*
  • Catalysis
  • Hydrocarbons, Chlorinated / chemistry*
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Lewis Acids / chemistry
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Potassium / chemistry*
  • Salts / chemistry

Substances

  • Alkynes
  • Hydrocarbons, Chlorinated
  • Ketones
  • Lewis Acids
  • Organometallic Compounds
  • Salts
  • Potassium