Abstract
An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-μM range.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Biflavonoids / chemistry
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Biflavonoids / isolation & purification*
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Biflavonoids / pharmacology*
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Catechin / chemistry
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Catechin / isolation & purification*
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Catechin / pharmacology*
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Malaria, Falciparum / drug therapy
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Molecular Structure
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Papua New Guinea
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development
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Proanthocyanidins / chemistry
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Proanthocyanidins / isolation & purification*
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Proanthocyanidins / pharmacology*
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Stereoisomerism
Substances
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Antimalarials
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Biflavonoids
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Proanthocyanidins
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myristicyclin A
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myristicyclin B
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procyanidin
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Catechin