Abstract
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). We assess the safety and tolerability of adoptive transfer of autologous cytotoxic T lymphocytes (CTLs) specific for the EBV latent membrane protein (LMP) in a patient with recurrent NPC. After infusion, the majority of pulmonary lesions were no longer evident, although the primary tumor did not regress.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Carcinoma
-
Epstein-Barr Virus Infections / complications*
-
Epstein-Barr Virus Infections / prevention & control
-
Humans
-
Immunotherapy, Adoptive / adverse effects*
-
Immunotherapy, Adoptive / methods*
-
Lung / pathology
-
Male
-
Nasopharyngeal Carcinoma
-
Nasopharyngeal Neoplasms / therapy*
-
Secondary Prevention
-
T-Lymphocytes, Cytotoxic / immunology*
-
Transplantation, Autologous / methods
-
Treatment Outcome
-
Viral Matrix Proteins / immunology
Substances
-
EBV-associated membrane antigen, Epstein-Barr virus
-
Viral Matrix Proteins